Psicologia clinica pedro sanchez escobedo pdf download


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    Psicologia Clinica Pedro Sanchez Escobedo Pdf Download

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    The present data suggest an association between changes in inflammatory mediators and the diagnosis of primary and substance-induced MDD, namely in CUD patients. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: All relevant data are within the manuscript and its Supporting Information files.

    These funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Competing interests: The authors have declared that no competing interests exist. Introduction Major depressive disorder MDD is the most prevalent comorbid mental condition in subjects with substance use disorders SUD and closely related to their poor prognosis.

    As expected, due to their marked clinical severity, these dual diagnosed patients also present considerable psychosocial acuteness and make greater use of health resources, including emergency services and psychiatric admissions [ 1 — 3 ].

    Among others, modulation of inflammatory mediators such as cytokines and chemokines has been recognized as a possible target. A growing body of literature has established that cytokines can play a critical role in the pathogenesis of both MDD [ 8 — 9 ] and SUD [ 10 — 13 ].

    Preclinical and clinical studies in MDD and SUD have reported alterations in the immune system and dysregulation of the hypothalamic-pituitary-adrenal axis HPA [ 14 — 15 ]. These changes result in a chronic inflammatory response and a disruption of brain integrity and homeostasis as consequence of neuroinflammation [ 16 ]. Chemokines, small chemoattractant proteins, also act as modulators in neuronal transmission and participate in the communication between glia and neurons [ 8 , 19 ].

    An increasing quantity of research has focused on the leading role of inflammatory mediators in the pathophysiology of a variety of psychiatric problems including bipolar [ 20 ] and post-traumatic stress disorders [ 21 ], schizophrenia [ 22 ], and MDD [ 23 ]. Stratford Font Family.

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